What Is Collagen Peptides? Benefits, Research & Safety

Collagen has been known since the mid-20th century as the primary structural protein of connective tissue. The concept of hydrolysing collagen for improved digestibility dates to the gelatin industry, where partial hydrolysis produces gelatin and further hydrolysis yields peptides. Scientific interest in the bioactive properties of specific collagen peptide fragments grew in the 2000s, particularly research from Japan showing that hydroxyproline-containing dipeptides (Pro-Hyp, Hyp-Gly) were absorbed intact and accumulated in skin. Major clinical research milestones include: - Studies by Proksch et al. (2014) demonstrating improved skin elasticity and moisture with oral collagen peptides - The DONA trial series examining collagen in osteoarthritis - Research by Oesser and Seifert showing collagen peptide accumulation in cartilage tissue - Studies demonstrating specific bioactive collagen peptides (e.g., VERISOL, FORTIGEL, TENDOFORTE) targeting skin, cartilage, and tendons respectively The collagen supplement market has grown rapidly, with global sales exceeding £5 billion. This commercial success has driven increasing research investment, with over 70 randomised controlled trials published to date.