Peptides for Migraine Prevention

NICE NG217 (headaches) and CG150 (migraine) frame UK migraine care. Acute attack: triptans (sumatriptan first-line) + NSAID / paracetamol; antiemetic for nausea. Preventive treatment if ≥4 migraines/month or significant disability: propranolol or topiramate first-line; amitriptyline, candesartan, sodium valproate (not in childbearing women) as alternatives; CGRP monoclonal antibodies (NICE-approved) after 3+ preventive failures. Lifestyle: identify and manage triggers (sleep, hydration, regular meals, caffeine consistency, stress management). Avoid medication-overuse headache from frequent acute treatment.

See your GP if migraines are frequent (≥4 per month), severe enough to disrupt work or daily life, not responding to OTC analgesia, or if pattern is changing. Urgent same-day assessment for: sudden-onset 'thunderclap' headache (possible SAH), headache with fever / neck stiffness (possible meningitis), headache with focal neurological signs, headache after head injury, headache with vision changes / weakness. Specialist neurology / headache-clinic referral for chronic migraine or treatment-refractory cases.